#113 – Manolis Kellis: Human Genome and Evolutionary Dynamics

Manolis Kellis is a professor at MIT and head of the MIT Computational Biology Group. He is interested in understanding the human genome from a computational, evolutionary, biological, and other cross-disciplinary perspectives. Support this podcast by supporting our sponsors: – Blinkist: https://blinkist.com/lex – Eight Sleep: https://eightsleep.com/lex – MasterClass: https://masterclass.com/lex If you would like to get more information about this podcast go to https://lexfridman.com/ai or connect with @lexfridman on Twitter, LinkedIn, Facebook, Medium, or YouTube where you can watch the video versions of these conversations. If you enjoy the podcast, please rate it 5 stars on Apple Podcasts, follow on Spotify, or support it on Patreon. Here’s the outline of the episode. On some podcast players you should be able to click the timestamp to jump to that time. OUTLINE: 00:00 – Introduction 03:54 – Human genome 17:47 – Sources of knowledge 29:15 – Free will 33:26 – Simulation 35:17 – Biological and computing 50:10 – Genome-wide evolutionary signatures 56:54 – Evolution of COVID-19 1:02:59 – Are viruses intelligent? 1:12:08 – Humans vs viruses 1:19:39 – Engineered pandemics 1:23:23 – Immune system 1:33:22 – Placebo effect 1:35:39 – Human genome source code 1:44:40 – Mutation 1:51:46 – Deep learning 1:58:08 – Neuralink 2:07:07 – Language 2:15:19 – Meaning of life