#845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment)

Dr. Dominic D’Agostino (@DominicDAgosti2) is a tenured associate professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine and a Visiting Senior Research Scientist at the Institute for Human and Machine Cognition. This episode is brought to you by:Gusto simple and easy payroll, HR, and benefits platform used by 400,000+ businesses: https://gusto.com/tim Seed's DS-01® Daily Synbiotic broad spectrum 24-strain probiotic + prebiotic: https://Seed.com/Tim David Protein Bars 28g of protein, 150 calories, and 0g of sugar: https://davidprotein.com/tim Coyote the card game​, which I co-created with Exploding Kittens: https://coyotegame.com* Timestamps:[00:00:00] Who is Dominic D'Agostino? [00:04:37] Ketosis benefits: Quieting the mind, GABA elevation, metabolic psychiatry.[00:09:24] My Lyme disease story: Pseudo-dementia reversed in 3-4 days of ketosis.[00:13:50] Spirochetes are glycolytic: Starve the bug, boost the immune response.[00:19:20] Ketosis and cancer: Slowing glycolytic tumors, enhancing standard care.[00:20:50] My 18-day keto experiment: Mood stabilization, Alzheimer’s prevention hopes.[00:23:19] Metabolic memory: Carryover effects and Valter Longo’s fasting mimicking research.[00:27:11] Intermittent fasting as keto on-ramp: My 2-8 p.m. eating window.[00:29:15] Dom’s budget keto meal: Canned mackerel, MCT oil, apple cider vinegar.[00:33:28] My ketone measurement paradox: Feeling sharp at 0.2 mM readings.[00:36:56] The carburetor analogy: Ketone production vs. utilization explained.[00:38:43] Breath ketones vs. blood ketones: Better indicator in caloric deficit.[00:39:47] Gluconeogenesis fears: Fat, fiber, and salt to slow protein absorption.[00:45:25] The bunless double cheeseburger question: 80 grams of protein in one sitting.[00:49:03] Post-meal walking and GLUT4 activation: Timing your glucose disposal.[00:51:02] CGM and ketone monitor limitations: When your devices gaslight you.[00:58